Effect of preoperative transarterial chemoembolization on prognosis of stage B hepatocellular carcinoma in BCLC classification
LIU Xin-hui
QI Yan-xia
LUO Rong-cheng
Abstract：Objective To investigate the effect of preoperative transarterial chemoembolization ( TACE) on the prog-nosis of stage B hepatocellular carcinoma (HCC) in the Barcelona Clinic Liver Cancer (BCLC) classification.Methods A total of 309 stage B hepatocellular carcinoma patients treated with hepatectomy were enrolled in our retrospective analy -sis, among whom, 136 patients underwent preoperative TACE and hepatectomy (TACE group) and 173 patients had only hepatectomy (non-TACE group).Independent-Samples t-test and Pearson χ2 test were used to analyze the clinical data of the two groups.Long-rank test and Cox regression models were used to compare the overall survival rates .Results There were no significant differences in clinical data between the two groups (P>0.05).The median survival time was 36 and 26 months for the TACE group and non-TACE group, respectively (χ2 =9.226, P<0.05).In the Long-rank univariate anal-ysis, different treatments, diameter of tumor, surgical margin status and the level of serum AFP were risk factors in influen-cing the survival HCC patients (P<0.05).Cox multivariate analysis showed that different treatment was an independent factor in affecting the prognosis of HCC patients (RR:1.576, 95%CI:1.157-2.146, P=0.004).Conclusion Pre-operative adjuvant TACE therapy may prolong the survival time in BCLC stage B HCC patients treated with hepatectomy .
Keywords：primary hepatocellular carcinomaBarcelona Clinic Liver Cancer classificationchemoembolizationo-verall survival
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 11-13 )