Association between ADAM10 promoter polymorphisms and risk of lacunar infarction
LI You
LIAO Feng
CUI Li-li
MA Guo-da
LI Ke-shen
Abstract：Objective To observe the changes of a disintegrin and metalloproteinase 10(ADAM10) promoter polymor-phisms and to investigate their correlations with the risk of lacunar infarction (LI).Methods Totally 173 patients (infarction group) with LI and 297 controls (control group) from the Department of Neurology of the Affiliated Hospital of Guangdong Medi-cal College were selected.Multiplex Snapshot was used to determine the genotype and allele frequencies of rs653765 and rs514049 polymorphisms of the ADAM10 gene.B-color Doppler ultrasonography was used to determine the carotid artery intima-media thickness (CIMT).The relationships between polymorphisms of the two sites and sex, age, CIMT in the infarction group were analyzed.Results The frequency of the ADAM10 rs653765 CC genotype carriers was significantly lower in the infarction group as compared with that of the control group (P=0.008 0), but in a recessive model, the frequency of CT+TT genotype was significantly higher (OR=0.54, 95%CI 0.36-0.81, P=0.002 9), and the ADAM10 rs653765 T allele was also signifi-cantly higher (OR=1.95, 95%CI 1.37-2.79, P=0.000 2).The genotype and allele frequencies of ADAM10 rs514049 had no significantly difference between the infarction group and the control group (P>0.05).Further stratification analysis on gender and age revealed that men carrying the ADAM10 rs653765 T allele conferred a higher risk of LI ( OR=1.51, 95%CI 1.00-2.28, P=0.048), and the individuals over 70 years old with the ADAM10 rs653765 CT genotype or T allele might run a higher risk of LI (OR=1.69, 95%CI 1.00-2.85, P=0.046).The genotype and allele frequencies of rs514049 were not statistically associated with LI, even after taking into account the patients'gender and age.Conclusion The present study suggests that the ADAM10 rs653765 T allele may be associated with the etiology of lacunar infarction.
Keywords：a disintegrin and metalloproteinase 10 genelacunar infarctiongene polymorphism
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 4-7 )