Effects of PDGF-BB on migration and proliferation of SK-BR-3 mammary carcinoma cells
BU Yu-hui
SHI Jian-hong
CUI Nai-peng
HE Huan
WANG Bing
CHEN Bao-ping
Abstract：Objective To explore the effects of platelet-derived growth factor ( PDGF)-BB on the migration and prolif-eration of SK-BR-3 mammary carcinoma cells .Methods SK-BR-3 mammary carcinoma cells in logarithm growth stage were treated with different concentrations of PDGF-BB (0.5, 1, 2, 4 ng/mL).The proliferation was determined by cytom-etry and MTS assay , and the migration ability was detected by cell migration assay .Results Compared with SK-BR-3 mammary carcinoma cells without any drug , 4 ng/mL PDGF-BB promoted the migration and proliferation of SK-BR-3 mam-mary cells and it was positively associated with the drug concentration .Conclusions The PDGF-BB can promote the mi-gration and proliferation of human SK-BR-3 cells in a specific concentration range .
Keywords：platelet-derived growth factor-BBSK-BR-3 mammary carcinoma cellscell migrationcell proliferation
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 5-7 )