Changes and significance of serum tumor markers in patients with esophageal carcinoma undergoing neoadjuvant chemoradiotherapy
LI Guang-xu
SONG Ping-ping
JIA Hui
LI Hao
ZHANG Shu-guang
ZHANG Bai-jiang
Abstract：Objective To discuss the dynamic changes of serum CYFRA 21-1, carcinoembryonic antigen (CEA) and carbohydrate antigen ( CA) 19-9 levels before and after neoadjuvant chemoradiotherapy to evaluate its efficacy and prognosis in treatment of patients with esophageal carcinoma .Methods The dynamic changes in serum levels of cytokeratin 19 frag-ment(CYFRA21-1), CEA and CA19-9 were observed during treatment and after treatment in 30 cases of patients who re-ceived neoadjuvant chemoradiotherapy with esophageal cancer resection .The relationship between the changes and the clin-ical efficacy and prognosis was analyzed .Results The median survival time of CEA positive people was significantly shor-ter than that of negative ones before treatment (P<0.05).The median survival time of CA19-9 positive people was shorter than that of negative ones ( because the positive cases were few , it was unable to statistical processing ) , and the median survival period of CYFRA21-1 positive and negative patients was not statistically different .During treatment, their median survival of those patients whose markers decreased was longer , and the effective rate was better than the increasing ones . Conclusions The dynamic and combined detections of serum CYFRA 21-1, CEA and CA19-9 in patients treated by preop-erative neoadjuvant chemotherapy can effectively evaluate the therapeutic effect and prognosis .
Keywords：esophageal carcinomaneoadjuvant radiotherapyneoadjuvant chemotherapycytokeratin 19 fragment (CYFRA21-1)carcinoembryonic antigencarbohydrate antigen 19-9
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 25-27 )