Mechanism of botulinum toxin type A in treatment of migraine of rats
ZHANG Xiao-ying
YANG Guo-dong
PAN Wan-long
Abstract：Objective To explore the mechanism of botulinum toxin type A ( BTX-A) in treatment of migraine of rats.Methods The migraine rat models were established and then were respectively given subcutaneous injection of BTX -A (BTX-A group) and normal saline (NS group); additionally, the healthy rats were selected as the control group .The contents of calcitonin gene related peptide ( CGRP) and substance P ( SP) were detected by radioimmunoassay .Results The contents of CGRP and SP in the NS group were higher than those of the control group , but they decreased significantly in the BTX-A group as compared with those of the NS group (all P<0.05).Conclusion BTX-A inhibits SP and CGRP releasing from trigeminal sensory pathways , which may be one of the mechanisms of BTX-A in treatment of migraine .
Keywords：botulinum toxinsmigraineneuropeptide
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 34-35 )