Expression of CYP1B1 and COX-2 in human breast cancer tissues and its correlation
WANG Xiao-hong
LIU Yi-xin
LI Hui-qiang
REN jie
SHI Yi-quan
GAO Jie
Abstract：Objective To investigate the expression of cytochrome P4501B1 (CYP1B1) and cyclooxygenase-2 ( COX-2) in the breast cancer tissues and its correlation.Methods A total of 123 cases of breast cancer tissues were divided into invasive breast cancer tissues, ductal carcinoma in situ ( DCIS) , benign epithelial proliferative lesions and adjacent normal tissues.Immunohistochemical method was applied to detect the expression of COX-2 and CYP1 B1 protein.The relationship between the expression of CYP1 B1 and COX-2 , and with clinicopathological fea-tures was analyzed.Results High expression of CYP1 B1 and COX-2 was found in the invasive breast cancer , DCIS and benign epithelial proliferative lesions, and low expression in the adjacent normal tissues.The CYP1B1 and COX-2 expression rates in the invasive breast cancer, DCIS and benign epithelial proliferative lesions were not significant different (all P>0.05), but were higher than that of the adjacent normal tissues (all P<0.05).The positive stai-ning intensity of CYP1 B1 and COX-2 in benign epithelial proliferative lesions was significantly decreased as compared with that of the invasive breast cancer and DCIS (all P<0.05).The expression of CYP1B1 was correlated with estro-gen receptor (ER) and progesterone receptor (PR) (all P<0.05).The expression of CYP1B1 was positively corre-lated with of the COX-2 expression (r =0.277,P =0.041).Conclusion COX-2 enhances the expression of CYP1 B1 and both of them take part in the occurrence and development of breast cancer .
Keywords：invasive breast carcinomacarcinoma in situbenign breast epithelial proliferative lesionscyclooxygen-ase-2cytochrome P4501B1
Publication Date：2014-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：4( 10-13 )