Study of mitochondrial DNA mutations in children with dilated cardiomiopathy
Abstract：PCR was used to detect 5Kb and 7．4Kb mitochondrial DNA（mtDNA） deletions in 15 child patients with dilated cardiomyopathy（DCM），13 cases with acute myocarditis（disease course less than 3 months） and healthy chldren in order to determine the role of mtDNA deletions in the etiology of DCM．All chilhdren detected had 5Kb and 7．4Kb mtDNA deletions，but the amount of deleted mtDNA in DCM patients were higher than those of myocarditis patients and healthy children（7．97％±3．51％，2．5％±1．64％and 2．28％±1．76％，respectively，P＜0．05）．The result indicate that mtDNA deletions are associated with part of DCM．
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 3-4 )