Influence of extradural block to humoral immune factors in patients with lumbar intervertebral disc prolapse
Abstract：To investigate the influence of extradural block to humoral immune factors in patients with lumbar intervertebral disc prolapse（LIDP）underwent.61 patients with LIDP were divided into group A（the projection of nucleus pulposus ≥0.5cm）and group B（the projection of nucleus pulposus＜0.5cm）.Serum was taken from two groups before and after extradural block and from 31 normal people （control group）.IgG，IgA，IgM and C3 in these samples were determined by radial immunodiffusion.Results showed that the serum IgG，IgM level before extradural block was higher in group A than group B and the control group（P＜0.05），there was no difference between group B and control group(P＞0.05），while the serum IgG，IgM，IgA and C3 level after extradural block was normal in group A. Its saggest that there are an autoimmunity inflammatory reaction and an abnormal humoral immunity in the patients with LIDP，and the bigger projection of nucleus pulposus the intenser autoimmunity inflammatory reaction.Extradural block can eliminate the autoimmunity inflammatory reaction of the nevve root and regulate the disturbed immunologic function of the patients with LIDP.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 12-14 )