Relationship between acute leukemia and soluble tumot hecrosis factor
Abstract：Serum tumor necrosis factor（TNFα），serum soluble tumor necrosisfactor receptor Ⅰ（sTNFR-Ⅰ）and soluble tumor necrosis factor receptor（sTNFR-Ⅱ）were detected with enzyme-link immunosorbent assay in 60 acute leukemia（AL） cases and 36 health subjects.The results showed：①Serum levels of sTNFR-Ⅰ and sTNFR-Ⅱ in 30 untrearted AL patients and 14 relapsed／refractory AL patients were significantly higher than those in controls（P＜0.001and P＜0.001），but in 16 bone marrow remission（BMR）AL patients its were not different from those in controls（P＞0.05）.Serum levels of TNFα in AL patients were significantly higher than those in controls（P＜0.001）.②There were remarkably positive relationship between serum TNFα and sTNFR-Ⅰ levels（r＝0.684，P＜0.01），two sTNFRs and peripheral blood blasts（r＝0.748，P＜0.001；r＝0.384，P＜0.05）.③The BMR rate was higher in those serum sTNFR-Ⅰ＜0.89μg／L than that in those sTNFR-Ⅰ≥0.89μg／L（χ２＝10.80，P＜0.01）．④Logistic regression analysis showed that serum sTNFR-Ⅰ＜2.0μg／L and peripheral blood blasts＜10×10９/L were associated with BMR.Those indicated the enhanced serum sTNFRs levels in AL might have relation to leukemic cells，course and drug response and the serum sTNFRs were an index of predicting prognosis.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 15-16 )