The expression of P16 and PCNA in bladder neoplasms
Abstract：62 patients with bladder transitional cell cancer for the firsttime were selected.The expression of P16 and PCNA was studied in consecutive tissue slides using S-P immunohistochemical technique.The results showed P16 expressed mostly in nuclear and its positive was 50.00％.PCNA expressed in nuclear and its positive percentage was 64.52％.There was negative correlation between P16 expression and the cancer’s grades，stages.Conversely PCNA expression was oppositely correlated to the cancer’s grades and stages.Statistical differences were observed for expression of P16 and PCNA between G1 and G3，superficial tumors（Tis～T1）and invasive tumors （T2～T4），the recurrence and non recurrence.These suggest that the detection of P16 and PCNA may be used to evaluate the behaviour of TCC.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 12-14 )