Homozygous deletion and methylation of P15 gene in acute laukemia
Abstract：To investigate the role of P15 gene in the pathegenesis ofleukemia，48 patients with newly diagnosed acute leukemia were studied.PCR technique was used to detect homozygous of P15 gene，restriction enzyme-PCR technique used to detect gene methylation.This results showed P15 gene inactivation was detected in 28 of the 48 patients.For all patients，methylation was the major pathway of P15 gene inactivation.Patients with P15 gene inactivation had a poor response to chemotherapy and a lower remission.This suggests that the methylation of P15 gene islands occurs very commonly in every types of AL.It can be used as a gene marker for AL and for minimal residual disease in CR.The inactivation of P15 gene plays a key role in the pathogenesis of acute leukemia.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 10-11 )