Clinical significance of apoptosis of bone marrow cells in patients with myelodysplastic syndromes
Abstract：Apoptosis of bone marrow mononuclear cells（BMMNC）was demonstratedusing terminal deoxytransferase（TdT）-mediated dUTP nick end labeling（TUNEL）method in 26 myelodysplastic syndromes（MDS）patients，11 megaloblastic anemia（MegA），8 paroxysmal nocturnal hemoglobinuria（PNH）and 6 Evans syndromes patients.Apoptosis was significantly increased in MDS，no difference of apoptosis was found between MegA，PNH，Evans syndromes and normal controls.Apoptosis was seen in myeloid blasts，maturing myeloid cells，nucleated erythroid cells and megakaryocyte cells in MDS patients.As MDS progressing，apoptosis gradually decreased.These results suggest that excess apoptosis is one of factors leading to ineffective hematopoiesis in MDS.MDS clinical progression may be associated with escaping from apoptosis of myelodysplastic progenitors.Therapy of anti-apoptosis could be used in early MDS patients.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 7-8 )