Expression and significace of mdr1 in patients with acute leukemia
Abstract：The expression of multi-drug resistance gene（mdr1 mRNA）wasmeasured in 36 patients with different type of acute leukemia and in 15 normal controls by fluorogenic probe quantitative RT-PCR（FQ-RT-PCR）.Result showed that the mdr1 mRNA was neg ative in normal controls． The average level of the mdr1 gene express in untreated group was 2.7×103 copies／μgRNA，while that of clinical resistance group was 1.0×104 copies／μgRNA（P＜0.05）.The CR rate differed significantly between mdr1 positive group（21％）and negative group（82％）（P＜0.05）.It suggests that FQ-RT-PCR is an acurate quantitative method in detecting the mdr1 gene expression，a high level of mdr1 expression correlated closely with drug resistance in clinical leukemia chemotherapy.
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Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 3-4 )