Relationship between serum cholesterol and low dense lipoprotein receptor activity of patients with acute myelogenous leukemia
Abstract：The serum cholesterol concentration and the rates of degradationof 125 I-low density lipoprotein（125I-LDL）by isolated leukemic cells of 52 patients with acute myeloblastic leukemia at diagnosis were assayed.The results showed that the lowest serum cholesterol concentrations were found in the patients with very high rates of cellular degradation of 125 I-LDL.After chemotherapy，both LDL cholesterol and total serum cholesterol levels rosed concomitantly with the fall in white blood cell counts.This suggests that a high receptor-mediated uptake and degradation of LDL by the leukemic cells may be the cause of hypocholesterolaemia in acute myeloblastic leukemia.LDL-receptor activity in leukemic cells may provide a basis for therapeutic approaches.
Machine-generated Keywords：
Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 1-2 )