Influence of prostglandin E1 and captopril on plasma endothelin-1 concentrations in chidren coith congenital heart defecfs
Abstract：In order to study the influence of prostglandin E1 and captoprilon plasma endothelin-1 levels in children with congenital heart defects（CHD）.Divided 33 CHD children into two groups randomly.Then gave them intravenous PGE1（PGE1 group） 20ng／（kg.min），or oral captopril（captopril group）1mg／（kg.d）for 15 days，and their femoral venous blood were accumulated（about 2ml）before and after the drug therapy，the plasma endothelin-1 concentrations were measured.Result showed that the plasma endothelin-1 concentrations were significantly higher in children with pulmonary hypertension than those normal subjects，and prostglandin E1 could significantly decrease the patients’ mean pulmonary hypertension and their plasma endothelin-1 levels，while captopril showed the trend to decrease the patients’ mean pulmonary hypertension and their plasma endothelin-1 levels，however it couldn’t reach the statistic levels.This suggests that the endothelin-1 antagonist may delay the development of pulmonary hypertension in children with CHD
Keywords：Congenital Heart Defects Endothelin-1 Prostglandin E1 Captopril
Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 8-9 )