Detection and siguificance of serum IL-12 and IgE in patients with asthma in attack
Abstract：To evaluate the relationship and the clinical significancebetween the serum IL-12 and IgE in the patients with asthma in attack.Sandwich ELISA was used to detect the IL-12 and IgE level in the sera of 27 cases of patients with athma in attack.SPSS statical software was used to analysis the reletive of IL-12 and IgE.Results showed that the serum IL-12 in 27 cases of patients with asthma in attack was 71.70±81.43pg／ml，it decresed significantly comparing with the health voluteer donor，which is 196.32±94.33pg／ml.To the contrast，serum IgE in patients was 2078.63±611.79pg／ml，which significantly increaed comparing with the normal（327.16±125.28pg／ml）.Linear regression showed that the decrease of IL-12 relate to the increase of IgE（R＝-0.667）.The results suggest that insufficient production of IL-12 imped the differenciation of Th1.Biased Th2 response may be dominat in the immune response of the asthma in attack.
Keywords：IL-12 IgE Asthma Th1／Th2 Responsion
Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：2( 6-7 )