Relationship between cytokins and bone resorption and bone metastasis of Lung cancer
Abstract：In order to verify the relationship among some cytokins and boneresorption，bone lesion caused by bone metastasis of lung cancer，the bone resorption test were developed using neonatal mouse calvaria to examine the bone resorbing activity（BRA）of IL-1，IL-6，TNF and the PBMCs of lung cancer patients with multiple bone metastasis.At the same time，the levels of IL-1，IL-6，TNF were measured in 30 patients with bone metastasis of lung cancer，20 cases with multiple bone lesions.Results showed that the IL-1，IL-6，TNF could stimulate bone resorption respectively，and IL-1 was the most potent stimulator.PBMCs of lung cancer patients with bone metastasis conld streng then BRA significantly.there was an obvious difference comparing with control group and normal ? individuls.The IL-6 levels of lung cancer patients with multiple bone metastasis significantly higher than that of the controls（P＜0.05）.These results suggest that some cytokins have close relation with bone resorption and bone lesion in lung cancer.The level of serum IL-6 may be a meaningful parameter in judging the severity of bone lesions in lung cancer patients.
Keywords：Cytokins Bone resorption Bone metastasis of lung cancer
Publication Date：2001-01-01
Online Publishing Date：2025-08-15(First online date of this platform, not the publication date of the document)
Pages：3( 1-3 )