Research Progress on Construction and Evaluation of Animal Models for Ulcerative Colitis with Spleen-Kidney Yang Deficiency Syndrome
WANG Jing
HE Xiaoqin
HUANG Xiaoting
ZHANG Bisheng
WEI Yu'na
Abstract：The disease-syndrome combined animal model,constructed based on the concept of syndrome differentiation and treatment,serves as a crucial approach for investigating the mechanisms underlying traditional Chinese medicine's intervention in the spleen-kidney yang deficiency syndrome in ulcerative colitis(UC).Analyzing the advantages and limitations of existing methods can offer insights and references for establishing a standardized disease-syndrome combined animal model and its associated evaluation systems.Through a comprehensive review of the recent literature on animal models of spleen-kidney yang deficiency syndrome in UC,this study has found that the current construction of such animal models in UC primarily combines the etiology and pathology-based modeling method with the chemical reagent method.The models constructed using this approach possess advantages such as high success rate,good stability,typical pathological changes,and high clinical con-sistency.However,the method of establishing models by combining etiology and pathology has the problem of non-unified drug administration cycle and dosage.The model evaluation system encompasses macroscopic characterization,physical and chemical indicators,and syndrome verification via formulas,presenting a relatively comprehensive approach.Nevertheless,the weights of each indicator remain unclear.There are 60 references.
Keywords：ulcerative colitisspleen-kidney yang deficiency syndromeanimal modelmolding methodevaluation method
Publication Date：2026-04-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：8( 435-441,448 )