Efficacy Observation of Tiandan Qiyang Decoction(天丹启阳汤)in Treatment of Erectile Dysfunction of Kidney Yin Deficiency Type

WANG Jian; TENG Fengmeng; LU Yang; TIAN Lei; ZHU Yejin; CAO Chengxu; PIAO Zhenrong; YE Siyuan; XIAO Jinlong; SUN Zihao; XUE Yifan; ZHANG Maosen

doi:10.16295/j.cnki.0257-358x.2026.04.010

Abstract：Objective:To evaluate the clinical efficacy and safety of Tiandan Qiyang Decoction(天丹启阳汤)in the treatment of erectile dysfunction(ED)of kidney yin deficiency type.Methods:Based on the order of visit,150 ED patients of kidney yin deficiency type were divided into an observation group of 100 cases and a control group of 50 cases.Due to the drop-out cases during the treatment period,92 cases in the observation group and 41 cases in the control group actually completed the full course of treatment and follow-up.The observation group was treated with oral Tiandan Qiyang Decoction,while the control group was treated with a oral decoction prepared from the herbs used in Zuogui Pill(左归丸).Both groups received continuous treatment for 4 weeks.The curative efficacy on erectile function,score of the International Index of Erectile Function-5(IIEF-5),score of the Erection Quality Scale(EQS),score of traditional Chinese medicine(TCM)syndromes,levels of five sex hormones,blood lipid levels,uric acid(UA)levels,liver and kidney function,as well as adverse reactions were compared between the two groups.Results:After treatment,the total efficacy of erectile function in the observation group was better than that in the control group,and the difference was statistically significant(P＜0.05).After treatment,the IIEF-5 score and the EQS score in both groups were increased compared with those before treatment(P＜0.01),and the IIEF-5 score and the EQS score in the observation group were higher than those in the control group(P＜0.05).After treatment,the TCM syndrome scores in both groups were decreased compared with those before treatment(P＜0.01),and the TCM syndrome score in the observation group was lower than that in the control group(P＜0.05).After treatment,the serum testosterone level in the observation group was increased compared with that before treatment(P＜0.05)and was higher than that in the control group(P＜0.05).There were no statistically significant differences in the levels of liver and kidney function,blood lipids,and UA between the two groups before and after treatment(P＞0.05),and no obvious adverse reactions occurred in the patients of both groups during the treatment period.Conclusion:Tiandan Qiyang Decoction can effectively improve the erectile function and TCM clinical symptoms of ED patients of kidney yin deficiency type.Its curative efficacy is better than that of the decoction prepared from the herbs used in Zuogui Pill,and it is safe for clinical application.