Clinical Study on Shengmai Powder(生脉散)in Prevention and Treatment of Cardiac Injury Caused By Postoperative Radiotherapy(Including Internal Mammary Region Irradiation)for Left-Sided High-Risk Breast Cancer
JIN Yuting
ZHANG Yu
WANG Jiali
CHEN Xiaoyu
MA Jun
Abstract：Objective:To observe the effects of Shengmai Powder(生脉散)on cardiac injury and traditional Chinese medicine(TCM)syndromes in patients with left-sided high-risk breast cancer who undergo radiotherapy(including internal mammary region irradiation)after surgery.Methods:A total of 67 patients with left-sided high-risk breast cancer after surgery were randomly divided into an observation group of 35 cases and a control group of 32 cases.The patients in both groups received intensity-modulated conformal radiotherapy including the internal mammary region.On this basis,the patients in the observation group took a decoction prepared from the herbs used in Shengmai Powder orally from the day when radiotherapy started until 3 months after the end of radiotherapy.Since 2 cases dropped out during treatment in the control group,35 patients in the observation group and 30 patients in the control group completed the follow-up.The total incidence of radiation-induced cardiac injury,the levels of cardiac function indicator[left ventricular ejection fraction(LVEF)],myocardial injury-related biomarkers[high-sensitivity cardiac troponin Ⅰ(hs-cTnI)and N-terminal pro-brain natriuretic peptide(NT-proBNP)],and TCM syndrome scores were compared between the two groups.Results:After treatment,the total incidence of radiation-induced cardiac injury in the observation group(5.71％)was lower than that in the control group(16.67％),but the difference was not statistically significant(P＞0.05).The difference in LVEF between 24 months after treatment and before treatment in the observation group was smaller than that in the control group,and the difference was statistically significant(P＜0.05).After treatment,the dry mouth score of the observation group was lower than that before treatment and also lower than that of the control group,and the differences were statistically significant(P＜0.05).Conclusion:For patients with left-sided high-risk breast cancer who undergo radiotherapy(including internal mammary region irradiation)after surgery,Shengmai Powder shows a trend toward reducing the incidence of radiation-induced cardiac injury,delay the decline in left ventricular function,and release the symptom of dry mouth.
Keywords：Shengmai Powderbreast cancerradiotherapycardiac injuryleft ventricular ejection fractionhigh-sensitivity cardiac troponin ⅠN-terminal pro-brain natriuretic peptide
Publication Date：2026-04-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：8( 390-397 )