Analysis of Evolution of Immune Inflammation and NLR in Acute Myocardial Infarction and Its Intervention Strategies from Perspective of"Phlegm Combined with Blood Stasis Forming Ke'nang"
FENG Tongtong
WEI Xiaoyu
ZHANG Rui
PANG Jianzhong
Abstract：The occurrence and development of acute myocardial infarction(AMI)are closely related to the dynamic evolution of immune inflammation.The neutrophil-lymphocyte ratio(NLR),as a novel indicator reflecting the balance of immune inflammation,holds significant value in assessing the occurrence and progression of AMI.However,the intrinsic relationship between NLR abnormalities and the underlying immune-inflammatory imbalance,as well as its dynamic evolution during the course of AMI,remains to be further elucidated.Guided by the theory of"phlegm combined with blood stasis forming the Ke'nang(a pathological lesion characterized by coagulated phlegm and blood stasis)",this article focuses on the high consistency in the pathological essence between the"Ke'nang"and the"immune inflammation-thrombosis"network from the perspective of the interaction between the pathogenesis of deficiency of healthy qi with phlegm and blood stasis,and immune inflammation,and explores the associations between them and the occurrence and development of AMI.The dynamic imbalance of immune inflammation is the microscopic manifestation of the pathogenesis of deficiency of healthy qi with phlegm and blood stasis,and abnormal NLR can serve as a potential microscopic indicator for identifying this pathogenesis and judging the prognosis.Based on this,a therapeutic strategy centered on regulating qi,activating blood circulation,resolving phlegm,and eliminating blood stasis is further proposed for the critical stage of the acute phase of AMI characterized by the binding of phlegm and blood stasis and the formation of the Ke'nang,offering new insights for the clinical differentiation and treatment of AMI.
Keywords：acute myocardial infarction(AMI)immune inflammationneutrophil-lymphocyte ratio(NLR)deficiency of healthy qi with phlegm and blood stasisKe'nang
Publication Date：2026-04-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：9( 352-359,372 )