Clinical Study on the Treatment of Perianal Eczema with Quyang Huashi Formula(祛痒化湿方)Fumigation Combined with Mayinglong Musk Hemorrhoid Ointment(马应龙麝香痔疮膏)

FENG Li; WANG Bo; WANG Xiang; XUE Chang; ZHANG Feng; JIN Xin

doi:10.16295/j.cnki.0257-358x.2026.03.011

Abstract：Objective:To explore the therapeutic effect of Quyang Huashi Formula(祛痒化湿方)fumigation combined with Mayinglong Musk Hemorrhoid Ointment(马应龙麝香痔疮膏)in the treatment of perianal eczema(excessive damp-heat type)and its impact on the immune function of patients.Methods:A total of 102 patients with perianal eczema were randomly divided into the fumigation group,the hemorrhoid ointment group,and the combination group according to the random number table method,with 34 patients in each group.The fumigation group was treated with the Quyang Huashi Formula fumigation,the hemorrhoid ointment group was treated with Maying-long Musk Hemorrhoid Ointment,and the combination group was treated with Quyang Huashi Formula fumigation combined with Mayinglong Musk Hemorrhoid Ointment.The traditional Chinese medicine(TCM)syndrome scores,inflammatory factor levels,immune index levels,clinical efficacy,and adverse reaction occurrence were compared among the three groups of patients.Results:After treatment,the TCM syndrome scores of all three groups decreased,and the combination group had a lower score(P＜0.05);after treatment,the levels of tumor necrosis factor-α(TNF-α)and interleukin-4(IL-4)in all three groups decreased,and the combination group had a lower level(P＜0.05);after treatment,the levels of interferon-γ(IFN-γ)in all three groups increased,and the combination group had a higher level(P＜0.05);after treatment,the levels of immunoglobulin E(IgE)and eosinophils(EOS)in all three groups decreased,and the combination group had a lower level(P＜0.05);after treatment,the total effective rate of the combination group(97.06％)was higher than that of the fumigation group(79.41％)and the hemorrhoid ointment group(73.53％)(P＜0.05),and the overall efficacy comparison among the three groups showed a statistically significant difference(P＜0.05);during the treatment period,no obvious adverse reactions occurred in all three groups of patients.Conclusion:Quyang Huashi Formula fumigation combined with Mayinglong Musk Hemorrhoid Ointment can relieve the clinical symptoms of patients with perianal eczema,reduce inflammatory responses,regulate the body's immune function,and has a relatively high safety.