Clinical Observation on Huoxue Huayu Ointment(活血化瘀膏)in Treatment of Autologous Arteriovenous Fistula Stenosis

SHA Xin; HUANG Ping; MENG Lingdong; YAN Zhongyu; LIU Xiaojing

doi:10.16295/j.cnki.0257-358x.2026.02.011

Abstract：To explore the effects of Huoxue Huayu Ointment(活血化瘀膏)on the intimal hyperplasia injury and hemodynamics,serum lipoprotein-associated phospholipase A2(Lp-PLA2),interleukin-10(IL-10)and other indicators in patients with autologous arteriovenous fistula(AVF)stenosis.Methods:A total of 90 patients with AVF stenosis were selected and divided into a control group and an observation group according to the random number table method,with 45 cases in each group.The control group was given external application of Mucopolysaccharide Polysulfate Cream,while the observation group was given external application of Huoxue Huayu Ointment.One course of treatment was 4 weeks,and a total of 3 courses of treatment were given.The patients were followed up for 6 months.The AVF patency rate of the two groups was compared.The hemodynamic indicators(blood flow,inner diameter of blood vessels)before and after treatment in the two groups were detected,and the endometrial thickness before and after treatment in the two groups was measured.And various laboratory indicators[Lp-PLA2,IL-10,high-density lipoprotein(HDL),neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),triglycerides-glucose index(TyG)]before and after treatment were compared.Results:Three months after the treatment,the patency rate of AVF in the observation group was 66.67％,which was higher than 40.00％in the control group(P＜0.05).Six months after treatment,the patency rate of AVF in the observation group was 75.56％,which was higher than 51.11％in the control group(P＜0.05).Three months after treatment,the blood flow and inner diameter of blood vessels in both groups increased compared with those before treatment,and the observation group was higher than the control group(P＜0.05).Three months after treatment,the endometrial thickness in both groups was lower than that before treatment,and the thickness in the observation group was lower than that in the control group(P＜0.05).Three months after treatment,the levels of serum Lp-PLA2,NLR,PLR and TyG in both groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P＜0.05).Both IL-10 and HDL were increased compared with those before treatment,and the observation group was higher than the control group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P＞0.05).The total effective rate of the observation group was 68.89％,which was higher than that of the control group at 46.67％(P＜0.05).Conclusions:Huoxue Huayu Ointment can significantly increase the patency rate of AVF by inhibiting inflammation through multiple targets,improving hemodynamics,and reducing intimal hyperplasia injury.