Effects of Sangzhu Yangzheng Herbal Tea(桑术养正饮)on Immune Function and Oropharyngeal Microorganisms of Population after SARS-CoV-2 Infection
MA Dabao
ZHANG Lei
WANG Xuerui
WANG Jiabo
XU Xiaolong
LIU Qingquan
Abstract：Objective:To observe the effects of Sangzhu Yangzheng Herbal Tea(桑饮)on the immune function and oropharyngeal microorganisms of population after SARS-CoV-2 infection.Methods:Sixty subjects infected with the SARS-CoV-2 from December 7,2022 to December 31,2022 were recruited and divided into a control group and a traditional Chinese medicine group according to the random number table method,with 30 cases in each group.The traditional Chinese medicine group was treated with oral administration of Sangzhu Yangzheng Herbal Tea,while the control group received no intervention.The observation period was 2 weeks.The levels of T lymphocyte subsets(including the counts of CD3+T cells,CD4+T cells,and CD8+T cells)before observation and on the 14th day after observation were compared between the two groups.16S rRNA sequencing was performed on throat swab samples of patients in the traditional Chinese medicine group before and after treatment respectively to evaluate the diversity and composition of oropharyngeal microbiota,and to conduct microbiota difference analysis.Results:On the 14th day after observation,the levels of CD3+T cells,CD4+T cells and CD8+T cells in the traditional Chinese medicine group all increased compared with those before treatment(P＜0.05).The levels of CD3+T cells,CD4+T cells and CD8+T cells in the control group decreased compared with those before observation(P＜0.05).On the 14th day after observation,the levels of CD3+T cells,CD4+T cells and CD8+T cells in the traditional Chinese medicine group were higher than those in the control group(P＜0.01).After treatment,the Alpha diversity(Ace,Chao and Sobs indices)in the traditional Chinese medicine group was all increased compared with that before treatment(P＜0.05).The composition of the microbiota at the phylum level was mainly composed of Firmicutes,Bacteroides,etc.At the genus level,dominant genera such as Streptococcus,Rothia,and Prevotella accounted for a significant proportion.After treatment,the relative abundance of Prevotella,Isprevotella,Cilium,Catococcus and Peptostreptococcus in the traditional Chinese medicine group increased compared with that before treatment(P＜0.05).No obvious adverse reactions occurred in either group.Conclusion:Sangzhu Yangzheng Herbal Tea can improve the T-cell immunity of people after SARS-CoV-2 infection,improve the structure of oropharyngeal microorganisms,and has good safety.
Keywords：SARS-CoV-2 infectionimmune functionmicroorganismSangzhu Yangzheng Herbal TeaChinese herbal tea
Publication Date：2026-02-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：6( 168-173 )