Clinical Observation on Tongfeng Pill(痛风丸)Combined with Febuxostat in Treating Patients in Remission Period(Phlegm Turbidity and Blood Stasis Syndrome)

MA Chunxia; LIU Chen; LI Hong; FAN Xinyi; DENG Xiuqin; CUI Shikui

doi:10.16295/j.cnki.0257-358x.2026.01.009

Abstract：Objective:To observe the clinical efficacy of the Tongfeng Pill(痛风丸)combined with febuxostat in the treatment of gout in the remission period.Methods:A total of 60 patients with gout in the remission stage with phlegm turbidity and blood stasis syndrome in traditional Chinese medicine(TCM)were included and randomly divided into the observation group and the control group by using the random number table method,with 30 cases in each group.The control group was treated with oral febuxostat,while the observation group was treated with Tongfeng Pill combined with febuxostat.The treatment period was 12 weeks.The recurrence rate of gout during the treatment period was observed;Blood uric acid(BUA)levels before and after treatment,inflammatory indicators levels[C-reactive protein(CRP),erythrocyte sedimentation rate(ESR)],Visual Analogue scale(VAS)for pain,and TCM syndrome score were compared;The changes in tophi area,the volume of joint effusion and the infrared thermal aberration value between the affected side and the healthy side of the joint were detected by musculoskeletal ultrasound before and after treatment.Results:After treatment in both groups,the recurrence rate was 53.30％in the control group and 36.70％in the observation group.The Log-rank test showed a statistically significant difference(P＜0.05).Compared with that before treatment,the relative baseline changes of BUA,CRP,ESR,VAS and TCM syndrome score in the control group were smaller than those in the observation group,and the differences between the groups were statistically significant(P＜0.05).Tophi area size,joint effusion volume and infrared thermal aberration values in both groups improved compared with those before treatment,with greater improvements in the observation group.The effective rate of the control group was 76.70％,and that of the observation group was 86.7％.The efficacy grade of the observation group was higher than the control group(P＜0.05).Conclusions:Compared with the treatment with Western medicine alone,Tongfeng Pill combined with febuxostat has a lower risk of recurrence in the treatment of gout in the remission period(phlegm turbidity and blood stasis syndrome).It can effectively reduce blood uric acid levels and relieve clinical symptoms,and has good safety.It is expected to prevent and treat hyperuricemia and prevent gout recurrence,and is worthy of promotion.