Exploration on Correlation between"Spleen Acting as the Protector of the Body"and Tumor Immunity from Perspective of Intestinal Mucosal Immune Homeostasis
YUAN Yamin
DAI Yining
LI Huijie
LI Xiurong
Abstract：The pathogenesis of tumors is very complex.Modern research suggests that their occurrence and development are closely related to the immune function of the body.Regulating the function of the immune system is a key approach of tumor prevention and treatment.Intestinal mucosal immunity is an important component of the immune system,which can affect the prognosis of diseases and intervene in the therapeu-tic effect.Traditional Chinese medicine(TCM)holds that"spleen acting as the protector of the body",which is a highly summarized description of the spleen's defense function through the medium of defensive qi.The immune site of the intestinal mucosa is located in the intestine,and its function belongs to the spleen,which is highly consistent with the theory in TCM that"spleen acting as the protector of the body".The imbalance of intestinal mucosal immune homeostasis is similar to the pathological transformation process of"spleen acting as the protector of the body-the spleen failing to act as the protector of the body",and"the spleen failing to act as the protector of the body"may be the mechanism of tumor occurrence in TCM.This article takes"spleen acting as the protector of the body"as the entry point to explore the correlation and clinical application between the imbalance of intestinal mucosal immune homeostasis in tumors and"the spleen failing to act as the protector of the body",in order to provide a theoretical basis for the prevention and treatment of tumors from the perspective of"treating the spleen and regulating the protector of the body"to restore intestinal mucosal immune homeostasis.
Keywords：tumorintestinal mucosal immunityspleen acting as the protector of the bodyspleen failing to act as the protector of the bodytumor immunity
Publication Date：2026-01-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：6( 17-22 )