Observation on the Therapeutic Effect of Shenling Baizhu Decoction(参苓白术汤)Combined with Continuous Renal Replacement Therapy on Patients with Sepsis Accompanied by Acute Kidney Injury
LAI Maolin
YAN Xueli
YUAN Hua
LI Ping
ZHU Jing
WANG Li
CHEN Yinsong
HE Liang
LI Yongxin
Abstract：Objective:To explore the efficacy of Shenling Baizhu Decoction(参苓白术汤)combined with continuous renal replacement therapy(CRRT)in treating patients with sepsis of spleen deficiency and dampness-excess type accompanied by acute kidney injury(AKI).Methods:A total of 80 patients with sepsis of spleen deficiency and dampness-excess type accompanied by AKI were selected and divided into a control group and an observation group by using random number table method,with 40 cases in each group.Patients in the control group underwent CRRT,while the observation group was treated with Shenling Baizhu Decoction on the basis of the treatment of the control group.The Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE-Ⅱ)score,sepsis-related organ failure assessment(SOFA)score,inflammatory indicators(white blood cells,neutrophils,high-sensitivity C-reactive protein,procalcitonin),renal function indicators[urea nitrogen(BUN),serum creatinine(Scr)],therapeutic effects of traditional Chinese medicine(TCM)syndrome,and 7-day and 28-day mortality rates were compared between the two groups.Results:The APACHE-Ⅱ,SOFA,inflammatory indicators and renal function indicators of both groups of patients decreased compared with those before treatment.Moreover,the levels of APACHE-Ⅱ,BUN and Scr in the observation group were lower than those in the control group,and the differences were statistically significant(all P＜0.05).The therapeutic effect of TCM syndromes in the observation group was better than that in the control group,and the difference was statistically significant(P＜0.05).There was no statistically significant difference in the 7-day and 28-day mortality rates between the two groups(P＞0.05).Conclusion:Shenling Baizhu Decoction can significantly alleviate the condition of sepsis with AKI and promote the recovery of renal function,but it does not show obvious improvement in inflammatory levels and prognosis in a short period of time.
Keywords：sepsisacute kidney injuryspleen deficiency and dampness excess syndromeShenling Baizhu Decoctioncontinuous renal replacement therapy
Publication Date：2025-12-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：7( 1331-1336,1351 )