Analysis of Traditional Chinese Medicine Dominant Population of Prostate Cancer Castration Syndrome and Clinical Study on the Intervention of Jianpi Yishen Formula(健脾益肾方)
WANG Jiazheng
CHEN Haoran
ZHU Xudong
CHEN Yafei
WANG Yilin
LIU Hao
Abstract：Objective:To analyze the characteristics of the dominant population in the treatment of prostate cancer castration syndrome with traditional Chinese medicine(TCM)and observe the clinical efficacy of the Jianpi Yishen Formula(健脾益肾方).Methods:This study adopts a two-stage design.The first stage is a observational study.A total of 380 patients with prostate cancer castration syndrome were selected and treated with TCM syndrome differentiation and treatment for 4 weeks.The changes in the prostate cancer quality of life(FACT-P)score and the characteristics of TCM syndrome types of the patients before and after treatment were observed.According to the FACT-P scores before treatment,the patients were divided into three groups:Group(70,90],Group(90,110]and Group(110,130].The second stage is a randomized double-blind controlled trial.120 patients who met the characteristics of the dominant population for TCM treatment were selected and divided into the observation group and the control group according to the random number table method,with 60 cases in each group.On the basis of castration treatment,the observation group was given the Jianpi Yishen Formula and the control group was given a placebo.The treatment course for both was 4 weeks.The FACT-P scores,TCM syndrome scores,and levels of testosterone and prostate-specific antigen(PSA)of the two groups of patients before and after treatment were observed and compared.Results:A total of 374 patients completed the study in the first stage.After treatment,the FACT-P scores of the 374 patients as a whole and in the(90,110]group increased compared with those before treatment(P＜0.01),and the difference in the improvement range of FACT-P scores among the three groups was statistically significant(P＜0.01).The improvement range of the(90,110]group was higher than that of the other two groups(all P＜0.01).According to the analysis of TCM syndrome types,patients with deficiency of both spleen and kidney account for 46.0％,which is higher than that of other syndrome types.The second-stage study showed that the FACT-P scores of observation groups increased after treatment compared with those before treatment,and the observation group was higher than the control group(P＜0.05).The TCM syndrome score of the observation group was lower than that before treatment and was also lower than that of the control group after treatment(P＜0.05),and the therapeutic effect of TCM syndrome was better than that of the control group(P＜0.05).There was no statistically significant difference in the levels of testosterone and PSA between the two groups of patients compared with those before treatment(P＞0.05),and the castration levels were maintained.Conclusions:The FACT-P scores of patients with prostate cancer castration syndrome in the(90,110]range are the dominant population for TCM treatment,and spleen and kidney deficiency is the characteristic syndrome of TCM in this population.Jianpi Yishen Formula has a good therapeutic effect on prostate cancer castration syndrome.
Keywords：prostate cancercastration syndrometraditional Chinese medicine dominant populationspleen and kidney deficiencyJianpi Yishen Formula
Publication Date：2025-12-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：8( 1323-1330 )