Exploration on the Mechanism of Growth and Metastasis of Malignant Tumors and Their Differentiation and Treatment from Collateral Diseases Theory
WANG Ningjie
GU Ning
GU Yu
ZHANG Yiyang
XIN Huifang
LI Zhigang
Abstract：When the collateral vessels are normal,they flow smoothly;when they change,disease occurs;when the diseased collaterals arise,the collateral disease is formed.Malignant tumors are typical collateral diseases,featuring long-term persistence,blood stasis(pain),stubbornness and complexity in the clinical characteristics of collateral diseases.Obstruction of the collaterals,endogenous generation of cancer toxins,and deficiency of the collaterals are the basic collateral-related pathogenesis of malignant tumors,running through all stages of their growth and metastasis.Tumor neovascularization is similar to collaterals(collateral diseases)in structure,function and pathogenesis.The formation of the collateralsis is often related to hyperactivity of the collaterals,proliferation of diseased collaterals,tortuosity and disorder,stasis of the collaterals,deficiency of the collaterals and instability of the collateral qi.The therapeutic methods should have different focuses at different stages,such as eliminating pathogenic factors and detoxifying,calming hyperactivity and inhibiting the collaterals,promoting blood circulation and removing blood stasis,dispersing stagnation and dredging the collateral,or tonifying qi and consolidating the collaterals,nourishing the collaterals.Based on the perspective of the theory of collateral diseases and in combination with modern oncology research,this paper explores the growth and metastasis mechanism of malignant tumors as well as the clinical strategies.It holds that both traditional Chinese medicine and Western medicine should be involved throughout the process to form a lasting synergy and jointly achieve the goals of reducing toxicity and increasing efficacy,improving the quality of life,and prolonging the survival period of patients.
Keywords：collateralcollateral diseasesmalignant tumorobstruction of the collateralsendogenous generation of cancer toxinsdeficiency of the collaterals
Publication Date：2025-12-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：6( 1307-1312 )