Research Progress on Neutrophil Extracellular Traps in Lung Cancer Based on the Theory of "Blood Stasis and Toxin"
ZANG Jimiao
JIANG Yiyang
ZHANG Wei
XU Fei
Abstract：Neutrophil extracellular traps(NETs)are DNA-protein complex reticular structures released by activated neutrophils.NETs promote the pathological progression of lung cancer by mediating the release of inflammatory factors,promoting tumor-associated thrombosis and disrupting the homeostasis of the microen-vironment.Traditional Chinese medicine(TCM)believes that blood stasis accumulates internally and leads to toxin generation on the basis of a deficiency of healthy qi,which subsequently induces pathological changes,and ultimately results in the interweaving of stasis and toxins,which is one of the core pathogenic mechanisms of lung cancer.The hypercoagulable state of blood and hemodynamic changes mediated by NETs can be analogized to the TCM pathogenesis of"obstruction of blood vessels due to blood stasis",while the NETs-induced release of inflammatory factors leading to malignant imbalance of the microenvironment corresponds to the"accumulation of pathogenic toxins"arising from"deficiency of healthy qi".These two processes are causally linked and mutually reinforcing,jointly forming the pathological state of"intermingled stasis and toxin".Focusing on lung cancer,this article integrates traditional Chinese theory with modern medical research,elaborates on the correlation between NETs and the TCM concepts of stasis and toxin,and summarizes the mechanisms by which Chinese medicine exerts anti-lung cancer effects through the inhibition of NETs formation,with a prospect of providing scientific support for the therapeutic rationale of Chinese medicine in lung cancer treatment.
Keywords：lung cancerblood stasis and toxinneutrophil extracellular traps(NETs)inflammationthrombosistraditional Chinese medicine therapy
Publication Date：2025-12-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：10( 1292-1301 )