Exploration on Pathogenesis of PMS/PMDD from Incompatibility Between Chongren and HPO Axis

LIU Huayuan; WANG Yufang; MENG Qingyan; GUO Yinghui

doi:10.16295/j.cnki.0257-358x.2025.11.003

Abstract：Premenstrual syndrome(PMS)and its severe type,premenstrual dysphoric disorder(PMDD),are common diseases among women of childbearing age,seriously disturbing their normal lives and receiving increasing attention.According to traditional Chinese medicine,the core pathogenesis of PMS and PMDD is the liver's failure in governing conveyance and dispersion,and it is closely related to the imbalance of the Chong and Ren meridians.Based on the circulation and visceral relationship of the Chongren meridians,and the functional correspondence between the"kidney-Tiangui-Chong and Ren-uterine cavity"reproductive axis of traditional Chinese medicine and the hypothalamic-pituitary-ovarian(HPO)axis of western medicine,this article reveals the role of Chongren meridians incompatibility and the mechanisms of hormonal rhythm disorder and negative feedback abnormality,etc.in the pathogenesis of PMS/PMDD.The periodic abrupt changes of qi and blood in the Chong and Ren meridians can lead to disorders of liver,spleen and kidney functions,which subsequently triggers premenstrual emotional and physical symptoms;whereas HPO-axis sex hormone fluctuations exacerbate premenstrual-related symptoms by affecting neurotransmitters and central responsiveness.Through multi-targeted regulation of Chongren meridians and HPO axis functions,TCM can improve luteal function and endocrine status,providing new ideas for the clinical treatment.By integrating the theories of traditional Chinese and western medicine and deepening the modern scientific connotation of the theory of liver storage in traditional Chinese medicine,a bridge is built for the mechanism research and diagnosis and treatment practice of PMS/PMDD.