ZHANG WEI's Experience in Treating Pulmonary Nodule from Perspective of"Blood Stasis and Toxin"

LIU Xiangyang; XU Fei; LI Chang; ZANG Guodong; ZHANG Wei

doi:10.16295/j.cnki.0257-358x.2025.11.002

Abstract：Based on the theory of"blood stasis and toxin",Professor ZHANG Wei has developed a differen-tiation and treatment approach for pulmonary nodule.He proposes that the core pathogenesis lies in lung qi deficiency with stagnation and obstruction of lung collaterals by phlegm,blood stasis and toxin pathogens,which is characterized by the syndrome of fundamental deficiency and symptomatic excess.Clinically,he employs the therapeutic principle of"tonifying the lungs as the fundamental principle while eliminating stasis and attacking toxins",emphasizing the importance of reinforcing lung and spleen to consolidate constitutional foundation;regulating liver and kidney to promote qi and blood circulation;harmonizing spleen function and eliminating toxins to resolve nodules.Combining classic medical principles with clinical practice,he develops"Huajie Powder Ointment(化结散膏)",which eliminates the stasis and toxins of the disease and replenishes the vital energy of the lungs,achieving a combined effect of attacking and tonifying,thereby"supporting the body's healthy qi without leaving any pathogenic factors and eliminating pathogenic factors without harming the body's healthy qi."In clinical practice,Professor ZHANG emphasizes the integration of the four diagnostic methods,and flexibly adjusts the prescription according to the coexisting symptoms of phlegm,blood stasis and toxins,and applies insect-derived medications to eliminate latent pathogens strategically,which provides novel therapeutic strategies for the treatment of chronic and stubborn refractory pulmonary nodule.One test case is attached.