Effect of Yangxin Decoction(养心汤)Combined with Metoprolol on NT-proBNP,Heart Rate Variability and Efficacy in Patients with Arrhythmia
ZHAI Wenji
DENG Limei
DAI Hongxu
Abstract：Objective:To explore the effect of Yangxin Decoction(养心汤)combined with metoprolol on N-terminal B-type natriuretic peptide(NT-proBNP),heart rate variability and efficacy in patients with ventricular arrhythmia.Methods:Eighty patients with ventricular arrhythmia were randomly divided into control group and research group,40 patients in each group.The control group was treated with oral administration of metoprolol,and the research group was further treated with oral administration of Yangxin Decoction.Both groups were treated for 3 months.The total clinical effective rate and adverse reactions of the two groups after treatment were recorded.The traditional Chinese medicine(TCM)syndrome scores,the levels of serum high-sensitivity C-reactive protein(hs-CRP),NT-proBNP and adiponectin(APN)were detected before and after treatment.The standard deviation of all sinus beats(SDNN),standard deviation of mean sinus beats(SDANN),and the percentage of successive normal cardiac interbeat intervals greater than 50 msec(pNN50)were recorded by 24-hr continuous dynamic electrocardiogram recorder.Results:The total effective rate of the research group(75.00％)was higher than that of the control group(52.50％)(P＜0.05).After the treatment,in both groups the TCM syndrome scores,hs-CRP and NT-proBNP levels decreased,APN,SDNN,SDANN and pNN50 increased(P＜0.05).There was no statistically significance in adverse reactions between the two groups of patients.Conclusion:Yangxin Decoction combined with metoprolol can effectively reduce NT-ProBNP in serum of patients with ventricular arrhythmia with improved efficacy.
Keywords：Yangxin Decoctionmetoprololventricular arrhythmiaN-terminal B-type natriuretic peptide
Publication Date：2025-10-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：6( 1121-1126 )