Effects of Fumigation and Washing with Self-Prepared Wubeizi Decoction(自拟五倍子汤)on Postoperative Wounds and Intestinal Flora in Patients with Anal Fistula
YANG Yingnan
YUAN Zhiqiang
WANG Dongqin
CHEN Yu
Abstract：Objective:To observe the changes in the local microenvironment of the wound surface and in the intestinal flora of patients after anal fistula surgery following fumigation and washing with Self-Prepared Wubeizi Decoction(自拟五倍子汤),and to explore the therapeutic effect of this treatment on postoperative wound.Methods:A total of 80 patients who had undergone anal fistula surgery were selected and divided into a control group and an observation group,with 40 cases in each group,according to the random number table method.The control group received conventional surgical treatment combined with warm water fumigation and washing,while the observation group received conventional surgical treatment combined with Self-Prepared Wubeizi Decoction fumigation and washing.Both groups were treated for two weeks.The clinical efficacy,wound conditions,levels of local microecological indicators(pH value,lactic acid concentration,colony count),and intestinal flora structure were compared between the two groups.Results:The total effective rate of the observation group was 95.00％,and that of the control group was 80.00％.The difference in clinical curative effects between the two groups was statistically significant(P＜0.05).After 2 weeks of treatment,the length,width,depth,area,and volume of the wound surfaces in both groups were reduced compared to those before treatment(P＜0.05),and the values in the observation group were smaller than those in the control group(P＜0.05).The wound healing time of the patients in the observation group was shorter than that of the control group(P＜0.05).After 2 weeks of treatment,the wound pH values,lactic acid concentrations,and colony counts in both groups of patients all changed.Compared with those before treatment,the differences were statistically significant(P＜0.05).The observation group exhibited lower wound pH and lactate levels,fewer anaerobic bacteria,and a higher number of lactobacillus compared to the control group,and the differences were statistically significant(P＜0.05).After 2 weeks of treatment,there were statistically significant differences in the intestinal flora diversity indices(Shannon index and Simpson index)of the patients in both groups compared with those before treatment(P＜0.05).The diversity indices of intestinal flora in the observation group were higher than those in the control group(P＜0.05).The proportions of Firmicutes,Bacteroidetes,Bacteroidia,and Actinobacteria in the observation group were higher than those in the control group(P＜0.05),while the proportions of Proteobacteria and Firmicutes classes were lower than those in the control group(P＜0.05).Conclusions:The fumigation and washing with Self-Prepared Wubeizi Decoction can improve the local microenvironment of the anal fistula wound surface and promote wound healing.Its mechanism may be related to the regulation of the intestinal flora.
Keywords：Self-Prepared Wubeizi Decoctionfumigation and washinganal fistulapostoperative woundwound microenvironmentintestinal flora
Publication Date：2025-09-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：7( 1010-1015,1022 )