Clinical Study on Pinggan Quzhuo Granules(平肝祛浊颗粒)in Treatment of Grade 2 Essential Hypertension of Liver Yang Hyperactivity Type
WANG Jianming
LIU Ning
YANG Tianci
DU Zhipeng
FU Haoran
BU Xiaohan
ZHANG Fengxia
Abstract：Objective:To evaluate the clinical efficacy of Pinggan Quzhuo Granules(平肝祛浊颗粒)in treating patients with Grade 2 essential hypertension of the liver yang hyperactivity type and its impact on their quality of life.Methods:A total of 160 patients with Grade 2 essential hypertension of the liver yang hyperactivity type were enrolled and randomly divided into an observation group and a control group,with 80 patients in each group.Both groups adopted a healthy lifestyle for hypertension management.The control group additionally received valsartan capsules,while the observation group received Pinggan Quzhuo Granules in addition to the control group's treatment.Both groups were treated continuously for 4 weeks.The clinical blood pressure levels,ambulatory blood pressure levels,traditional Chinese medicine(TCM)syndrome scores,carotid intima-media thickness(CIMT),scores on Duke's Hypertension Quality of Life Scale,and safety indicators of the patients in the two groups were compared before and after treatment.The TCM syndrome improvement and blood pressure-lowering effects were evaluated in both groups.Results:After treatment,the clinical blood pressure levels,ambulatory blood pressure levels,TCM syndrome scores,and CIMT of the patients in both groups were lower than those before treatment(P＜0.05),and the values in the observation group were lower than those in the control group(P＜0.05).After treatment,the scores on Duke's Hypertension Quality of Life Scale of the patients in both groups were higher than those before treatment(P＜0.05).Moreover,except for the dimensions of interpersonal sensitivity and hostility,the scores in all other dimensions in the observation group were significantly higher than those in the control group(P＜0.05).No obvious adverse events occurred during the treatment process in both groups.After treatment,the total effective rate of TCM syndrome and the blood pressure reduction in the observation group were both higher than those in the control group(P＜0.05).Conclusion:Pinggan Quzhuo Granules can safely,effectively,and steadily reduce blood pressure,decrease the risk of target organ damage,and improve the quality of life in patients with Grade 2 essential hypertension of the liver yang hyperactivity type.
Keywords：Pinggan Quzhuo GranulesGrade 2 essential hypertensionhyperactivity of liver yangambulatory blood pressurequality of life
Publication Date：2025-09-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：9( 993-1000,1009 )