Treatment of Sjögren's Syndrome-Associated Interstitial Lung Disease from Perspective of"Cold-Dryness Causing Blood Stasis"Under Guidance of"Blood Stasis-Toxin"Theory
MOU Hongyu
ZHANG Wei
Abstract：The pathogenesis of Sjogren's syndrome-associated interstitial lung disease(SS-ILD),the most severe respiratory complication of Sjogren's syndrome,has not been fully elucidated.Although Western medicine primarily relies on glucocorticoids combined with immunosuppressants for treatment,its effectiveness remains limited.Based on the holistic syndrome differentiation and treatment system of traditional Chinese medicine,this article proposes that the intermingling of blood stasis and toxin is the core pathogenesis of SS-ILD,and the mutual impairment of cold and dry pathogenic factors is the key to its pathogenesis.External cold stirs up dryness,while internal cold consumes yang qi,resulting in the disorder of the distribution of qi,blood,and body fluids,thus forming a pathological mechanism chain reaction of"extreme cold transforming into dryness-excessive dryness causing blood stasis-prolonged blood stasis transforming into toxin".During the pathological process,the cold pathogen stagnates and blocks the collateral vessels,the dry pathogen injures body fluids and causes the lung lobes to wither and atrophy,and the mutual binding of blood stasis and toxins accelerates the formation of masses in the lung collaterals.Therefore,for the treatment of SS-ILD,the therapeutic principles can be warming yang and moistening dryness,promoting blood circulation to remove blood stasis and detoxifying,so that when yang qi is properly distributed,yin fluid will recover spontaneously,and when cold is dispelled and dryness is eliminated,blood stasis and toxins will disappear naturally.
Keywords：Sjögren's syndromeinterstitial lung diseaseblood stasis-toxincold-drynesswarming yang and moistening drynesspromoting blood circulation to remove blood stasis and detoxifyingseeking yin within yang
Publication Date：2025-09-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：5( 954-958 )