Clinical Study on Yangxin Jianpi Tongmai Decoction(养心健脾通脉汤)in Treatment of Coronary Heart Disease Complicated with Ventricular Premature Beats
SHAO Zhencan
LIU Jinsong
TAO Yanli
LIU Zhihong
Abstract：Objective:To observe the effects of Yangxin Jianpi Tongmai Decoction(养心健脾通脉汤)on coronary microcirculation,sinus heart rate oscil-lations,circadian rhythm and autonomic nerve activity in patients with coronary heart disease complicated with ventricular premature beats.Methods:One hundred patients with coronary heart disease complicated with ventricular premature beats were selected and divided into a control group and an observation group,with 50 cases in each group,according to the random number table method.The control group received symptomatic treatment with Western medicine,while the observation group was treated with Yangxin Jianpi Tongmai Decoction on the basis of the treatment of the control group.The number of ventricular premature beats during the day and at night in the two groups of patients was recorded before and after treatment.The standard deviation of the mean NN interval every 5 minutes(SDANN),the total NN interval of sinus beats(SDNN)level were detected.The oscillation initiation values and oscillation slopes of the two groups were detected.The coronary microcirculation conditions(coronary circulation resistance index,blood flow reserve,peripheral resistance)were evaluated.The levels of creatine kinase isoenzyme,lipodroplet protein 5 and N-terminal pro-B-type natriuretic peptide were detected in both groups.The clinical efficacy was evaluated.Results:In the control group,one case dropped out due to loss to follow-up,and in the observation group,one case was excluded because the patient did not follow the prescribed medication.The cure rate and total effective rate of the observation group were higher than those of the control group(P＜0.05).After treatment,the number of ventricular premature beats during the day and at night in both groups decreased,and the number in the observation group was less than that in the control group(P＜0.05).After treatment,the levels of SDANN and SDNN in both groups decreased,and those in the observation group were lower than those in the control group(P＜0.05).After treatment,the initial values of oscillation in both groups decreased,and those in the observation group were lower than those in the control group(P＜0.05).The oscillation slopes in both groups increased,and those in the observation group were higher than those in the control group(P＜0.05).After treatment,the peripheral resistance in both groups decreased,and that in the observation group was lower than that in the control group(P＜0.05).The coronary circulation resistance index and blood flow reserve in both groups increased,and those in the observation group was higher than those in the control group(P＜0.05).After treatment,the average levels of creatine kinase isoenzyme and N-terminal B-type natriuretic peptide in both groups decreased,and the levels in the observation group were lower than those in the control group(P＜0.05).The levels of lipodroplet protein 5 in both groups increased,and the levels in the observation group were higher than those in the control group(P＜0.05).Conclusion:Yangxin Jianpi Tongmai Decoction can reduce myocardial injury,improve coronary microcirculation,the circadian rhythm of premature beats and autonomic nerve activity,and enhance clinical efficacy in the treatment of coronary heart disease complicated with ventricular premature beats.
Keywords：Yangxin Jianpi Tongmai Decoctioncoronary heart diseaseventricular premature beatcoronary microcirculationsinus heart rate oscillationcircadian rhythmautonomic nerve activity
Publication Date：2025-08-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：7( 886-892 )