Study on Effect of Tangzhiqing Granules(糖脂清颗粒)on Obese Patients with Type 2 Diabetes Mellitus(Phlegm and Blood Stasis Obstructing Collaterals Syndrome)

CHEN Le; LIU Jun; WANG Xu

doi:10.16295/j.cnki.0257-358x.2025.08.010

Abstract：Objective:To explore the effects of Tangzhiqing Granules(糖脂清颗粒)on glucose and lipid metabolism and micro-inflammatory status in obese patients with type 2 diabetes mellitus(phlegm and stasis obstructing collaterals syndrome).Methods:Eighty obese patients with type 2 diabetes mellitus(phlegm and stasis obstructing collaterals syndrome)were selected as the research subjects and divided into a control group and an observation group,with 40 cases in each group,according to the random number table method.While receiving basic treatment,the control group was treated with metformin,while the observation group was treated with Tangzhiqing Granules on the basis of the treatment of the control group.The therapeutic effects of traditional Chinese medicine(TCM)syndromes,degree of obesity,level of glucose and lipid metabolism,pancreatic islet function indicators,levels of inflammatory factors and safety were compared between the two groups.Results:The total effective rate of the therapeutic effect of TCM syndromes in the observation group was 90.00％,and that in the control group was 67.50％.The comparison of the therapeutic effects between the two groups showed a statistically significant difference(P＜0.05).After treatment the levels of body mass index(BMI),waist-hip ratio(WHR),glycosylated hemoglobin(HbA1c),free fatty acid(FFA),fasting blood glucose(FBG),2-hour postprandial blood glucose(PBG),insulin resistance index(HOMA-IR),C-reactive protein(CRP),and interleukin-6(IL-6)in both groups were lower than those before treatment.And the observation group was lower than the control group(P＜0.05).After treatment,the pancreatic β-cell function index(HOMA-β)of both groups was higher than that before treatment,and the observation group was higher than the control group(P＜0.05).After treatment,there was no statistically significant difference in adverse reactions between the two groups(P＞0.05).Conclusion:Tangzhiqing Granules can reduce the degree of obesity in obese patients with type 2 diabetes mellitus(phlegm and stasis obstructing collaterals syndrome),improve the disorder of sugar and lipid metabolism and insulin resistance,promote the recovery of pancreatic islet function,alleviate inflammatory responses,and its therapeutic effect is superior to that of simple western medicine treatment.