Exploration on the Mechanism of Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Inflammatory Bowel Disease Based on"Yang Transforming Qi,Yin Constituting Form"
YOU Jia
HUANGFU Shaohua
MA Chuanxue
LU Yafei
FANG Yuan
JIANG Bin
Abstract：Inflammatory bowel disease(IBD),including ulcerative colitis(UC)and Crohn's disease(CD),represents a group of chronic conditions characterized by recurrent inflammation of the digestive tract.By exploring the connection between"Yang transforming qi,yin constituting form"and IBD,it is proposed that the pathogenesis evolution of IBD follows the pattern of"insufficiency of yang transforming qi".Weakened qi transformation fails to warm and promote physiological activities,leading to stagnation of phlegm,fluid retention,and blood stasis—namely"excessive yin constituting form".Meanwhile,abnormal ascending and dispersing functions due to qi deficiency give rise to"yin fire",which burns the muscular interstices and consumes yin substances,resulting in"insufficient yin constituting form".Mesenchymal stem cell-derived exosomes(MSC-Exo),similar to the Chinese medical concept of"kidney essence",can transform into primordial qi after entering the body,treating IBD by dissipating yin fire,promoting qi circulation to remove stagnation,and facilitating qi transformation for substance formation.Qi-tonifying medicinals,based on the theory of"essence-qi transformation",can promote the transformation of kidney essence into primordial qi,thereby enhancing the effect of MSC-Exo in generating primordial qi and improving the therapeutic efficacy for IBD.
Keywords：yang transforming qiyin constituting forminflammatory bowel diseasemesenchymal stem cellexosomesqi-tonifying medicinals
Publication Date：2025-08-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：8( 840-847 )