Research Progress on Mechanisms of Yinyanghuo(Epimedii Folium)in Treatment of Parkinson's Disease
QIN Wenlu
ZENG Yuanning
WANG Qiuhong
Abstract：Parkinson's disease is a common neurodegenerative disorder of the nervous system,which is characterized primarily by the degeneration of dopaminergic neurons in the substantia nigra,leading to a reduction in dopamine neurotransmitters in the striatum and subsequent motor dysfunction.In recent years,Yinyanghuo(Epimedii Folium)has garnered widespread attention in the treatment of Parkinson's disease.This article reviews the mechanism of action of Yinyanghuo in the treatment of Parkinson's disease and elaborates on the specific mechanisms by which the main active components of icaritin and icariin,exert neuroprotective effects through antioxidation,improvement of mitochondrial dysfunction,inhibition of neuroinflammation,inhibition of neuronal cell apoptosis,and regulation of autophagy pathway,with a prospect of providing references and ideas for the clinical treatment of Parkinson's disease in the later stage.There are 46 references.inson's disease and summarizes its mechanisms of action,aiming to provide references for clinical treatment.
Keywords：Yinyanghuo(Epimedii Folium)icariinicaritinParkinson's diseasemechanism of action
Publication Date：2025-07-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：5( 824-828 )