Research and Practice on Theory of Visceral Manifestations of Liver
GUO Yinghui
SONG Chunhong
GAO Mingzhou
Abstract：Visceral manifestations theory of liver(LVMT)is one of the important contents of tradirional Chinese medicine(TCM)visceral manifestations theory.Deepening its scientific connotation and promoting its inheritance and innovation to guide clinical practice have been important propositions in the basic research of TCM.This article systematically reviews the development history and basic consensus of the research on LVMT,emphasizing that the physiological characteristic of"liver governing and regulating"is closely related to emotional disorders and gynecological diseases.However,its modern research still faces challenges such as theoretical and clinical disconnection and insufficient integration of traditional Chinese and Western medicine,which urgently needs key breakthrough points.Taking premenstrual syndrome(PMS)/premenstrual dysphoric disorder(PMDD)as the entry point,this paper reveals the deep association between liver dysfunction(either excessive or insufficient)and the neuroendocrine mechanism in Western medicine.It is proposed that the states of liver dysfunction,imbalance of Chong and Ren meridians,and disharmony of nutrient-defense in patients with PMDD are consistent with the functional abnormalities of the gamma-aminobutyric acid(GABA)ergic system,the negative feedback disorder of the hypothalamus-pituitary-adrenal(HPA)axis,and the immune disorder mechanism.From the perspective of constitution theory,the influence of genetic factors and environmental factors on the susceptibility to PMS/PMDD has been emphasized.Future research should be based on the holistic view of TCM,construct a four-dimensional framework of"phenomenon-data-mechanism-theory",integrate systems biology and artificial intelligence technologies,deepen the analysis of the microscopic regulatory network of the LVMT,promote complementary advantages of traditional Chinese and Western medicine,and facilitate the leap of TCM from empirical medicine to precision medicine.
Keywords：visceral manifestations of liverliver governing and regulatingemotional diseasespremenstrual syndromepremenstrual dysphoric disorderneuroendocrine mechanism
Publication Date：2025-07-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：7( 734-739,748 )