Research Progresses on Traditional Chinese Medicine Regulation of mTOR Signaling Pathway in Intervention of Ulcerative Colitis and Its Carcinogenesis
PANG Long
SUN Dajuan
CHI Lili
Abstract：One of the important factors of pathological damage in ulcerative colitis(UC)is the inflammatory response caused by abnormal immune response.The overexpression of inflammatory cytokine is an important factor promoting the transformation of inflammation to cancer,causing histopathological damage,inducing intraepithelial neoplasia,and forming tumors.The mammalian target of rapamycin(mTOR),as the core path-way regulating cell growth,autophagy and immune response,plays a dual role in UC and its carcino-genesis:on the one hand,it aggravates intestinal inflammation by inhibiting autophagy;On the other hand,it drives the proliferation of cancer cells.Studies have found that traditional Chinese medicine can regulate autophagy and inhibit inflammatory cytokine through pathways such as amp-activated protein kinase(AMPK)-mTOR and Akt-mTOR,with relatively low adverse reactions,providing potential therapeutic strategies for treating UC and inflammation-cancer transformation.Specifically,the active ingredients of traditional Chinese medicine such as berberine and phellodenine,as well as the traditional Chinese medicine compound Baitouweng Decoction(白头翁汤),can negatively regulate autophagy by activating the AMPK pathway,inhibit the phosphorylation of mTOR,promote autophagy in cells,and improve the inflammatory response of UC.Extracts of dried ginger,ginseng root,etc.can inhibit the Akt-mTOR pathway,reduce inflammatory cytokine secretion and intervene in cell apoptosis.There are 59 references.
Keywords：traditional Chinese medicineulcerative colitiscolorectal cancermammalian target of rapamycin(mTOR)inflammatory cancer transformation
Publication Date：2025-06-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：10( 711-720 )