Clinical Study on"Neck Seven-line Method"Acupuncture Combined with Xiaoyao Powder(逍遥散)on Patients with Insomnia due to Liver Depression Transforming into Fire
MAO Xuewen
SHEN Lingyu
DENG Yue
ZENG Qin
BAI Peng
Abstract：Objective:To explore the effect of"Neck Seven-line Method"Acupuncture combined with Xiaoyao Powder(逍遥散)on patients with insomnia due to liver depression transforming into fire.Methods:A total of 150 patients with insomnia who were treated in Shunyi Hospital of Beijing Hospital of Traditional Chinese Medicine from October 2022 to May 2024 were selected and divided into the traditional group,the Xiaoyao Powder group and the combination group of"Neck Seven-line Method"Acupuncture by using the random number table method,with 50 cases in each group(2 cases dropped out in the traditional group,2 cases dropped out in the Xiaoyao Powder group and 3 cases dropped out in the the combination group of"Neck Seven-line Method"Acupuncture).The traditional group received Western medicine treatment.The Xiaoyao Powder group received Xiaoyao Powde treatment on the basis of the treatment of the traditional group treatment,while the combination group of"Neck Seven-line Method"Acupuncture received"Neck Seven-line Method"Acupuncture treatment on the basis of the treatment of the Xiaoyao Powder group.After the treatment,the clinical efficacy of the three groups was compared,and the sleep structure indexes of the patients were detected before and after treatment:In total sleep time,the proportions of phase 1 sleep,phase 2 sleep,phase 3 sleep and rapid eye movement(REM)sleep were evaluated by the Pre-Sleep Arousal Scale(PSAS)and the Hyperarousal Scale(HAS).The expression levels of 5-hydroxytryptamine,S100 calcium-binding protein B,melatonin,excitatory neurotransmitter,interleukin-8 and neurofilament heavy chain were detected.Results:After the treatment,the total effective rate of the combination group of"Neck Seven-line Method"Acupuncture was 97.86％,which was higher than that of the traditional group(P＜0.05).The proportions of sleep in phase 1 and phase 2 in the combination group of"Neck Seven-line Method"Acupuncture were lower than those in before treatment and the traditional group and the Xiaoyao Powder group(P＜0.05).The proportions of sleep in phase 3 and REM in the combination group of"Neck Seven-line Method"Acupuncture were higher than those in the traditional group and the Xiaoyao Powder group(P＜0.05).The PSAS and HAS scores of the combination group of"Neck Seven-line Method"Acupuncture were lower than those of before treatment and the traditional group and the Xiaoyao Powder group(P＜0.05),and the PSAS and HAS scores of the Xiaoyao Powder group were lower than those of the traditional group(P＜0.05).The expressions of S100 calcium-binding protein B,interleukin-8 and neurofilament heavy chain in the combination group of"Neck Seven-line Method"Acupuncture were lower than those before treatment and the traditional group and the Xiaoyao Powder group(P＜0.05).The total expression of excitatory neurotransmitters in the combination group of"Neck Seven-line Method"Acupuncture was lower than that in the traditional group and the Xiaoyao Powder group(P＜0.05).The expressions of 5-hydroxytryptamine and melatonin in the combination group of"Neck Seven-line Method"Acupuncture were higher than those in before treatment and the traditional group and the Xiaoyao Powder group(P＜0.05).Conclusions:"Neck Seven-line Method"Acupuncture combined with Xiaoyao Powder can improve the level of neurotransmitter,reduce inflammation,improve awakening state,sleep structure and nerve damage,and enhance clinical efficacy in the treatment of patients with insomnia due to liver depression transforming into fire.
Keywords："Neck Seven-line Method"AcupunctureXiaoyao Powderinsomnianeurotransmitterawakening statesleep structurenerve injury
Publication Date：2025-06-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：7( 668-674 )