Clinical Observation of Qishen Fuling Formula(芪参茯苓方)in Treating Chronic Heart Failure

TANG Xue; CHENG Lirong

doi:10.16295/j.cnki.0257-358x.2025.06.008

Abstract：Objective:To observe the effectiveness of Qishen Fuling Formula(芪参茯苓方)in the treatment of chronic heart failure(CHF)of yang deficiency and blood stasis type.Methods:From March 2019 to September 2023,clinical data of 281 CHF patients with yang deficiency and blood stasis type was obtained retrospectively.Patients were divided into 3 groups according to the medications:140 cases in the western medicines group(routine western medicine therapy only);79 cases in the Qili Qiangxin Capsule(芪苈强心胶囊)group(Qili Qiangxin Capsule with routine western medicine therapy for one month);and 62 cases in the Qishen Fuling Formula group(Qishen Fuling Formula with routine western medicine therapy for one month).The clinical efficacy and its effects on traditional Chinese medicine(TCM)syndrome score,brain natriuretic peptide(BNP),carcliac troponin Ⅰ(cTn Ⅰ),left ventricular ejection fraction(LVEF),and the heart failure rehospitatization rate.indicators of the three groups were compared,and the independent factors that were clinically effective were determined using Logistic regression analysis.Observe and record the occurrence of adverse reactions during treatment.Results:The Qili Qiangxin Capsule group and Qishen Fuling Formula group both had higher overall clinical effective rates than the western medicine group(P＜0.05),and showed more obvious decrease of TCM syndrome score than the western medicine group(P＜0.05).The difference before and after treatment within the same group was statistically significant(P＜0.01).The Qishen Fuling Formula group was better than pre-treatment and the other two groups in terms of both heart failure rehospitalization rate decrease and LVEF elevation(P＜0.05).There was no difference in the between-group comparison of BNP and cTnⅠ levels before and after treatment in the three groups(P＞0.05).The Qili Qiangxin Capsule group and Qishen Fuling Formula group both had better clinical efficacy than the western medicine group(P＜0.05).Conclusions:Qishen Fuling Formula combined with routine western medicine showed better effect for CHF of yang deficiency and blood stasis type,and can improve the heart function and symptoms of heart failure obviously without obvious adverse reactions.