Exploration on the Correlation Between Latent Toxins Damage the Collaterals and Cellular Autophagy in the Pathogenesis of Pulmonary Interstitial Fibrosis
MA Xinlai
ZHANG Yang
ZHANG Wei
Abstract：Cellular autophagy helps to achieve cellular self-repair and maintain the balance of the intra-cellular environment and it plays a crucial role in processes such as cell growth,proliferation,senescence and apoptosis.It can regulate a variety of cytokines acting on pulmonary interstitial fibrosis(PF),and these regulatory effects are closely related to the occurrence and development of PF.The pathogenesis theory of latent toxins damaging collaterals in traditional Chinese medicine(TCM)has significant advantages in guiding TCM to delay the progression of PF.This article,guided by the theory of latent toxins in TCM and combined with modern clinical and scientific researches,analyzes the role of latent toxins in the development of PF.Treating PF based on the theory of latent toxins can achieve the goal of delaying its progression,and interfering with the expression process of autophagy in cells can also delay the development of the disease to a certain extent.Thus,it is speculated that there is a certain correlation between the theory of latent toxins in TCM and cellular autophagy.
Keywords：cellular autophagylatent toxinslung collateralslung impotencepulmonary interstitial fibrosis
Publication Date：2025-06-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：5( 620-624 )