Clinical Study on Jianpi Tongluo Prescription(健脾通络方)Combined with Chemotherapy for Treating Patients with Qi Deficiency and Blood Stasis Syndrome After Colorectal Cancer Surgery
CUI Wenwen
ZHANG Jie
YU Bianfang
GUAN Zhongan
Abstract：Objective:To evaluate the clinical efficacy and safety of the Jianpi Tongluo Prescription(健脾通络方)combined with the mFOLFOX6 chemotherapy regimen in treating patients with qi deficiency and blood stasis syndrome after colorectal cancer surgery.Methods:A total of 60 patients with qi deficiency and blood stasis syndrome after colorectal cancer surgery were divided into a control group and an observation group according to the random number table method,with 30 cases in each group.The control group was given chemotherapy with the mFOLFOX6 regimen,and the observation group was additionally given oral administration of the Jianpi Tongluo Prescription on this basis.Both groups took 14 days as one treatment cycle and received continuous treatment for 4 cycles.The traditional Chinese medicine(TCM)syndromes scores,Karnofsky performance status(KPS)score,and chemotherapy adverse reactions of the two groups of patients were compared,and the therapeutic effects on TCM syndromes in the two groups were evaluated.Results:After treatment,the main symptom score,secondary symptom score,and total score of TCM syndromes in both groups decreased significantly compared with those before treatment(P＜0.001).Moreover,the main symptom score,secondary symptom score,and total score of TCM syndromes in the observation group were all lower than those in the control group(P＜0.05,or P＜0.01,or P＜0.001).Additionally,the KPS score of patients in the observation group increased significantly compared with that before treatment(P＜0.001)and was higher than that of patients in the control group(P＜0.001).During the treatment,the degrees of leukopenia,nausea and vomiting,and diarrhea in the observation group were milder than those in the control group(P＜0.05).After treatment,the total effective rate of TCM syndromes in the observation group was higher than that in the control group.The difference of the curative efficacy on TCM syndromes between the two groups was statistically significant(P＜0.001).Conclusions:Compared with the simple mFOLFOX6 chemotherapy regimen,the Jianpi Tongluo Prescription combined with the mFOLFOX6 chemotherapy regimen can significantly relieve the clinical symptoms of patients with qi deficiency and blood stasis syndrome after colorectal cancer surgery,improve their functional status,reduce chemotherapy adverse reactions,and enhance the curative efficacy.
Keywords：Jianpi Tongluo PrescriptionmFOLFOX6 chemotherapy regimencolorectal cancerqi deficiency and blood stasistraditional Chinese medicine syndromes scoresKarnofsky performance status scorechemo-therapy adverse reactions
Publication Date：2025-05-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：6( 539-544 )