Exploration on Effect of Neutrophil Extracellular Traps on Pulmonary Fibrosis Based on the Theory of"Stasis and Toxicity"
YAN Guotao
XU Fei
LIU Huaman
ZHANG Wei
JIA Xinhua
Abstract：Pulmonary fibrosis(PF)is a chronic,progressive,and irreversible lung disease.Based on the theory of"stasis and toxicity",this paper takes neutrophil extracellular traps(NETs)as the breakthrough point,discusses the role of NETs in the occurrence and development of PF from the aspects that NETs can contribute to angiogenesis,enhance coagulation,promote thrombosis,drive epithelial injury,stimulate fibroblast activation,and activate inflammatory responses,and summarizes the key pathogenesis of NETs in the theory of"stasis and toxicity"and explore the role of NETs in the pathogenesis of PF,with a prospect of providing novel insights for the prevention and treatment of PF.
Keywords：neutrophil extracellular trapspulmonary fibrosisstasis and toxicityangiogenesisfibrinolytic imbalanceinflammatory immunity
Publication Date：2025-04-05
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：7( 378-384 )