Effect of Modified Bushen Huoxue Decoction(补肾活血汤)Combined with Thunder Fire Moxibustion on Osteoporosis of Kidney Deficiency and Blood Stasis Type
MA Jiaxing
SUN Xiaohong
ZHUANG Qi
LI Hong
QIAN Kewei
Abstract：Objective:To observe the therapeutic effect of modified Bushen Huoxue Decoction(补肾活血汤)combined with thunder fire moxibustion on osteoporosis(OP)of kidney deficiency and blood stasis type,and to provide references for traditional Chinese medicine(TCM)clinical prevention and treatment of OP.Methods:Eighty OP patients of kidney deficiency and blood stasis type were randomly divided into a control group and an observation group,40 patients in each group,using a random number table.The control group received conventional western medicine,while the observation group received additional Bushen Huoxue Decoction combined with thunder fire moxibustion alongside western medicine.The clinical efficacy of the two groups was evaluated after 8 weeks of treatment.Changes of TCM symptom scores before and after treatment were recorded.Bone mineral density(BMD)of lumbar vertebrae L4 and L5,femur,and tibia were measured using dual-energy X-ray bone densitometer.Pain intensity,lumbar and back function,and quality of life were assessed using visual analogue scale(VAS),Oswestry disability index(ODI)and 36-Item Short Form Survey(SF-36),respectively.Serum levels of bone γ-carboxyglutamate protein(BGP),β-collagen degradation product(β-CTX)and type Ⅰ procollagen amino terminal elongation peptide(PINP)were measured by enzyme-linked immunosorbent assay(ELISA).Results:There were no statistical differences between the observation group and the control group at baseline(P＞0.05).After 8 weeks of treatment,the observation group showed lower TCM symptom scores,VAS and ODI scores,as well as serum β-CTX levels(P＜0.05)compared to before treatment.BMD levels,quality of life score and levels of serum BGP and PINP significantly increased compared to baseline(P＜0.05).Compared to the control group,the observation group had a significantly higher total effective rate(P＜0.05).Additionally,the observation group exhibited significantly lower TCM symptom scores,VAS and ODI scores,and serum β-CTX levels,while BMD levels,quality of life scores and levels of serum BGP and PINP were significantly higher(P＜0.05).Conclusions:Modified Bushen Huoxue Decoction combined with thunder fire moxibustion has a good therapeutic effect on OP patients of kidney deficiency and blood stasis type by increasing bone density,alleviating pain,and improving quality of life.The therapeutic mechanism may involve the regulation of bone metabolism levels in patients.
Keywords：Bushen Huoxue Decoctionthunder fire moxibustionosteoporosiskidney deficiency and blood stasisbone metabolism
Publication Date：2025-02-04
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：6( 164-169 )