Discussion on the Disease Mechanism and Treatment of Sepsis-Associated Capillary Leakage Syndrome Based on the Theory of"Extreme Heat Injuring Collaterals"
XU Yifei
SUN Lili
LIANG Minghao
HUANG Di
JIN Minyan
CHEN Xianhai
QIU Zhanjun
Abstract：Disruption of the capillary endothelial barrier due to multiple risk factors is the main pathologic feature of sepsis associated capillary leakage syn-drome(SACLS).The collaterals are"overflowed with extraordinary evils,and communicate nutrient qi and defensive",with the function of communicating inside and outside,regulating qi and blood,and distribution of body fluids in the body.The concept of"extreme heat injuring collaterals"is a pathoge-netic concept put forward in Synopsis of the Golden Chamber,stating that when evils attack body,and there would be the tendency of cold and heat attributes in the meridians and collaterals,which provides an important etiological basis for the treatment of collaterals and collaterals-related diseases for the later generations.According to the pathological evolution of SACLS,we propose that"extreme heat arrives violently and damages the collaterals"is the core mechanism of the disease,and extreme heat is the source of poison,phlegm,blood stasis,and rheum.Damage to the collaterals is the source of imbalance in the circulation of qi,blood,yang,and body fluids.The therapeutic principle for different stages is listed as follows:in the pre-leakage stage,dispelling the evil heat should be applied mainly,which should be quick;in the leakage stage,activating blood and promoting diuresis,eliminating phlegm and rheum should be applied primarily;in the recovery stage,clearing collaterals and warming yang qi should be applied for the root.
Keywords："extreme heat injuring collaterals"sepsiscapillary leakage syndromecollateralsextreme heat arrives violently and damages the collaterals
Publication Date：2025-02-04
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：6( 145-150 )