New Insights into Etiology and Pathogenesis of Parkinson's Disease:Dominance of Toxic Pathogens and Gradual Erosion of Three Yin Meridians
LIU Jiawen
FU Fengming
NIE Linjun
ZHANG Xinyu
LIU Hongjie
Abstract：Based on long-term clinical and basic researches,a novel etiology and pathogenesis theory of Parkinson's disease,"dominance of toxic pathogens and the gradual erosion of the three yin meridians"has been proposed,along with corresponding treatment principles and methods.Specific toxic pathogens are the primary contributors to Parkinson's disease.Therefore,detoxification is the foremost therapeutic approach and permeates all treatment stages of Parkinson's disease.In the Taiyin stage,when the pathogenic factors invade the lung and the spleen,the nature of the syndrome is excess cold.The treatment should involve methods of dispelling wind,dissipating cold,resolving dampness,strengthening the spleen,and consolidating the exterior.In the concurrent stage of Taiyin and Jueyin,when the pathogenic factors invade the lung,spleen,liver,and pericardium,the nature of the syndrome is still mainly excess cold.The treatment should involve methods of strengthening the spleen,resolving dampness,regulating qi,expelling wind,restraining the liver,dissipate cold,and dredging collaterals.For those with predominant excess fire in Shaoyang,on the basis of the above,dissipating cold should be weakened and more emphasis should be placed on soothing Shaoyang and clearing phlegm-fire.In the concurrent stage of Taiyin,Jueyin,and Shaoyin,when pathogenic factors invade the five zang-organs and both primordial yin and primordial yang are deficient,the nature of the syndrome is a complex mixture of deficiency,excess,cold,and heat.The treatment should employ the method of replenishing both primordial yin and primordial yang,and the focus should vary depending on the patient's heat or cold properties.
Keywords：Parkinson's diseaseetiology and pathogenesistreatment principles and methodstoxic pathogenssix meridians
Publication Date：2025-01-04
Online Publishing Date：2026-05-22(First online date of this platform, not the publication date of the document)
Pages：5( 24-27,37 )